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The aim is to develop a conceptual understanding of pathological patterns (PPs) in relation to the COVID-19 pandemic, waves, and outbreaks. The concept of PPs is based on observations of PPs in elderly patients aged 65+ (2020-2025) in relation to COVID-19, acute respiratory viral infections, and acute respiratory infections. It is supported by our own publications on PPs in macro-systems of the body that are in contact with the external environment (using the examples of the skin and mucosal envelopes). The main provisions of the concept, and the principles of PP analysis are outlined. A personalized analysis of PP patients with signs of COVID-19 (lung damage, erythema and skin rashes, mucosal disorders in the absence or low titers of anti-COVID-19 antibodies), including those vaccinated and revaccinated against COVID-19, was conducted in connection with the pandemic and subsequent waves and outbreaks of COVID-19. The results indicate the high sensitivity of the body's macro-systems. Early and later short-term manifestations on the skin and mucosa of PP erythemas, rashes, and other types of lesions in connection with the COVID-19 pandemic and further seasonal manifestations of post-COVID syndrome and long COVID-19 have been established. Cascade chains have been identified that combine primary and secondary PPs in connection with the seasonality of COVID-19, including those that reflect changes in the circulatory system. Against the background of the similarity of the primary PPs in patients, the secondary PPs were characterized by an increase in the diversity of differences between patients, which could be represented as a personalized unique tree of the patient's pathologies. The contribution of the patient's existing pathologies (including chronic ones) to the formation of such a tree was noted. The branching of the tree during periods of long COVID-19 reflected the combined nature of the resulting PPs under the influence of acute respiratory viral infections and acute respiratory diseases. Based on a generalized analysis of the PPs of patients' macro-systems in contact with the external environment during periods of pandemic and later outbreaks of COVID-19, a concept of PPs has been proposed. The key terms of the concept have been described. The diagnostic and prognostic significance of the concept, as well as its connection to infection, have been assessed. The prognostic value of the concept lies in its ability to predict the development of characteristic early and later personalized PPs in relation to post-COVID-19. A classification of the PP topography has been provided. The approaches presented will help in the diagnosis, prognosis and prevention, and treatment of post-viral syndromes. The concept may allow further development of innovative therapeutic vectors for treatment of PPs 本研究旨在建立与COVID-19大流行、疫情波动及爆发相关的身体病理模式 PPs 概念性理解。PPs的概念基于对65岁及以上老年患者 2020-2025年 在COVID-19、急性呼吸道病毒感染及急性呼吸道感染背景下病理模式的观察 并结合我们关于与外界环境接触的身体宏系统 以皮肤和黏膜为例 PPs的相关研究成果。本文概述了该概念的主要内容及PPs分析原则。 在COVID-19大流行及随后的波动和爆发背景下 对表现出COVID-19相关特征的PPs患者 肺损伤、红斑和皮疹、黏膜功能障碍且抗COVID-19抗体缺失或滴度低 包括已接种或再接种疫苗的患者 进行了个体化分析。结果表明 身体宏系统具有高度敏感性。研究确认了PPs红斑、皮疹及其他损伤在皮肤和黏膜上的早期与晚期短期表现 并与COVID-19大流行及随后的季节性后COVID综合征和长期COVID-19相关。 研究发现了串联链 将初级和次级PPs与COVID-19的季节性联系起来 包括反映循环系统变化的链条。在初级PPs表现相似的背景下 次级PPs表现出患者之间差异的多样化 可呈现为患者个体化、独特的病理树结构。同时指出了患者既往病理 包括慢性病 对该树形成的贡献。长期COVID-19期间的树状分支反映了在急性呼吸道病毒感染和急性呼吸道疾病影响下产生的复合PPs特征。 基于对疫情及后续COVID-19爆发期间与外界接触的宏系统PPs的综合分析 提出了PPs概念 描述了其核心术语 评估了概念的诊断和预测意义及其与感染的关联。该概念的预测价值在于能够预测与后COVID-19相关的早期和晚期个体化PPs发展。文中提供了PPs部位的分类。提出的方法有助于病毒后综合征的诊断、预后、预防及治疗 并可能促进创新性治疗策略的发展 用于PPs的干预