Novel Bispecific Engagers Targeting the <scp>CεmX</scp> Domain of <scp>mIgE</scp> ‐Expressing Cells

20260 citationsJournal Articlehybrid Open Access

Authors

Constantin Möller · Universität Hamburg

Julia Hambach · Universität Hamburg

Alessa Z. Schaffrath · Universität Hamburg

Thomas Watts Eden · Universität Hamburg

Sophia Cichutek · Universität Hamburg

Anna Josephine Gebhardt · Universität Hamburg

Natalie Tode ·

Abstract

Our novel anti-CεmX TCE and HLE-NKCE effectively target and eliminate mIgE-expressing cells in vitro. Although further investigation is needed, our bispecific engagers are promising off-the-shelf therapeutics for the treatment of IgE-associated allergic diseases.

Topics & Keywords

Immune Cell Function and Interaction CAR-T cell therapy research Monoclonal and Polyclonal Antibodies Research

Publication Details

Published in: Allergy

DOI: 10.1111/all.70236

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Novel Bispecific Engagers Targeting the <scp>CεmX</scp> Domain of <scp>mIgE</scp> ‐Expressing Cells

Authors

Abstract

Topics & Keywords

Publication Details