Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses

20260 citationsJournal Article

Authors

Younghun Han · University of New Mexico

Jinyoung Byun · University of New Mexico

Caitlin J. VanLith · Mayo Clinic

Matthew A. Cooley · Mayo Clinic

Vikram R. Shaw · Baylor College of Medicine

Rikita Hatia · The University of Texas MD Anderson Cancer Center

Fowsiyo Ahmed ·

Abstract

Our large-scale GWAS highlights new genetic variants and HLA-linked mechanisms underlying CCA susceptibility. Integrating multi-step post-GWAS approaches enhances understanding of CCA pathogenesis and may facilitate the development of risk biomarkers for early detection and precision prevention strategies.

Topics & Keywords

Cholangiocarcinoma and Gallbladder Cancer Studies Genetic Associations and Epidemiology Liver Diseases and Immunity

Publication Details

Published in: Hepatology

DOI: 10.1097/hep.0000000000001699

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Uncovering the genetic landscape of cholangiocarcinoma and its subtypes via GWAS and integrative analyses

Authors

Abstract

Topics & Keywords

Publication Details