Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

20260 citationsJournal Articlehybrid Open Access

Authors

Ryunosuke Nagao · Fujita Health University

Kazuya Kawabata · Fujita Health University

Yasuaki Mizutani · Fujita Health University

Sayuri Shima · Fujita Health University

Akihiro Ueda · Fujita Health University

Mizuki Ito · Fujita Health University

Yasuhiro Maeda ·

Abstract

MSA exhibited a significant imbalance in KYN metabolism, suggesting a shift toward inflammatory processes distinct from classic neuroinflammatory markers. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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Tryptophan and brain disorders Treatment of Major Depression Parkinson's Disease Mechanisms and Treatments

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Published in: Movement Disorders

DOI: 10.1002/mds.70210

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Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy

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Abstract

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