Primary Amoebic Meningoencephalitis caused by Complement C2 Deficiency

20260 citationsJournal Articlegreen Open Access

Authors

Cui Jian · Vanderbilt University Medical Center

Colleen M. Roark · Vanderbilt University Medical Center

Nerea Domínguez-Pinilla · Research Institute Hospital 12 de Octubre

P. Nozal Aranda · Hospital Universitario La Paz

Begona Losada · Complejo Hospitalario Universitario de Toledo

Pilar Zamarrón · Hospital Virgen de la Salud

Jacob Lorenzo-Morales

Abstract

Our study demonstrates that PAM can be caused by a monogenic inborn error of immunity (IEI) and that the complement system is critical for human immunity against <i>Naegleria fowleri</i>.

Topics & Keywords

Legionella and Acanthamoeba research Bacterial Infections and Vaccines Amoebic Infections and Treatments

UN Sustainable Development Goals

Life in Land

Publication Details

Published in: medRxiv

DOI: 10.64898/2026.01.31.26345168

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