Multimodal Spatial Transcriptomics Reveals the Developing Human Liver Niche at Single-Cell Resolution

Integration of markers identified through spatial transcriptomics will expand molecular panel design and enable more precise characterization of developmental biliary biology and pathobiology. Importantly, RNA-based understanding of the functional diversity and in situ spatial organization of the developmental liver niche will also be essential for authenticating and re-engineering these complex regenerative environments in vitro.