Mapping the Global Burden and Inequalities of Bipolar Disorder, 1990–2021, With Projections to 2050: A Systematic Analysis

Global inequalities in bipolar disorder persist, disproportionately affecting females and high-SDI regions. Projected trends indicate an increasing burden with a narrowing gender gap in incidence, emphasizing the need for targeted interventions and further research on long-term impacts, including the effects of COVID-19.