Exploring the association between B-group vitamin deficiency and biomarkers for cardiometabolic disorders in patients with insulin resistance and prediabetes/type 2 diabetes mellitus

Introduction. Exploring the role of B-group vitamin deficiencies in patients with cardiometabolic disorders is important today. Aim. To study changes in biomarkers for cardiometabolic risk in patients with B-group vitamin deficiencies with underlying insulin resistance and carbohydrate metabolism disorders. Materials and methods. Seventy patients with abdominal obesity combined with prediabetes or type 2 diabetes were included, 35 of whom received Neuromultivit, 1 tablet twice a day, and 35 patients with abdominal obesity combined with prediabetes or type 2 diabetes who only received a backbone therapy. The observation period was 12 weeks. All patients underwent a preand post-observation examinations, including blood chemistry tests (C-reactive protein, lipid profile, glucose, HbA1C, insulin, homocysteine, B1, B6, and B12 vitamins) and neuropsychological testing such as MoCA test, Schulte Table test, and the Clinical Global Impression (CGI) -based assessment. Results. During Neuromultivit therapy, improvements were noted in the following parameters: a 0.6 [0.4; 0.9] ng/ml increase in vitamin B1 level (p < 0.001), a 4.6 [3.7; 7.7] ng/m increase in vitamin B6 level (p < 0.001), B12 level by + 256 [202; 474] pg/ml (p < 0.001); homocysteine level decreased by -2.2 [-2.5; -1.6] μmol/l (p < 0.001), glucose level by 0.17 [-0.23; -0.12] mmol/l (p < 0.001); HbA1c level by -0.04 [-0.05; -0.04] % (p = 0.002), insulin level by -0.5 [-0.8; -0.3] μIU/ml (p < 0.001), waist circumference (WC) decreased by -4 [-6; -3] cm (p < 0.001), the MoCA test result improved by +1 [1; 2] score (p < 0.001), the Schulte Table tests showed boosting in speed by -2.1 [-2.3; -1.5] sec, p < 0.001), CGI-I-based assessment demonstrated “significant improvement” in a greater number of patients (p < 0.001). In the control group, no significant positive changes were observed in any of the parameters studied. Conclusions. Neuromultivit therapy resulted in significant replenishment of B-group vitamin deficiencies, improvement of cardiometabolic parameters and cognitive functioning as compared to the control group.