Endogenous <scp>GIP</scp> signaling is indispensable for <scp>DPP</scp> ‐4 inhibitor‐mediated metabolic control in mice

Endogenous GIP signaling is essential for both glucose-lowering and anti-obesity actions of DPP-4 inhibitors in mice. GLP-1 elevation alone is insufficient to compensate for GIP receptor deficiency. These findings refined the mechanistic understanding of DPP-4 inhibitors, highlighted the physiological importance of GIP, and suggested context-dependent metabolic actions of incretins.