Downregulation of RORα by alcohol promotes TGFβ and α-SMA expression in mouse lung fibroblasts

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Authors

Xian Fan · Pulmonary and Allergy Associates

Hui Tao · Pulmonary and Allergy Associates

Bum-Yong Kang · Cystic Fibrosis Foundation

Nicolás M. Díaz · Morehouse School of Medicine

Kenkichi Baba · Morehouse School of Medicine

Gianluca Tosini · Morehouse School of Medicine

Justin Guo ·

Abstract

Ethanol disrupts circadian signaling and enhances profibrotic gene expression in lung fibroblasts, partly through suppression of RORα. RORα activation mitigates these effects, identifying RORα as a potential therapeutic target for ethanol-related maladaptive lung repair.

Topics & Keywords

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis Chronic Obstructive Pulmonary Disease (COPD) Research Occupational exposure and asthma

Publication Details

Published in: Frontiers in Medicine

Volume 13, pp. 1719787-1719787

DOI: 10.3389/fmed.2026.1719787

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Downregulation of RORα by alcohol promotes TGFβ and α-SMA expression in mouse lung fibroblasts

Authors

Abstract

Topics & Keywords

Publication Details