The integration of plasma non-target metabolomics and lipidomics analysis for the discovery of global developmental delay/intellectual disability biomarkers

This study identified putative biomarkers and metabolic pathways associated with GDD/ID, highlighting the potential of combined plasma metabolomics and lipidomics for early screening of GDD/ID and providing tentative insights into its pathophysiology. The biomarkers show strong diagnostic performance as screening tools, but future studies are needed to validate their prognostic value and clinical utility in multi-center cohorts.