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As the world enters the data-driven Fourth Industrial Revolution (Industry 4.0), industries face growing challenges and pressures related to digital technology adoption. Digital twins (DTs) technology, increasingly incorporated into complex, human-centered healthcare systems, has been identified as one of the top technological trends for the coming three years. DTs technology is increasingly viewed as a potential engine of the next healthcare revolution, especially for frontline healthcare workers, for whom DTs may serve as a transformative tool for reshaping how care is defined. Before expanding the application of DTs in health and healthcare, clinicians must first understand the underlying concepts. Only then will they be able to use this technology effectively in addressing clinical problems and improving care quality. In this article, the authors introduce the concept of DTs, outline current applications across different fields, describe potential future developments, and identify the challenges and future directions for DTs technology. Future research should continue to examine issues of accessibility, effectiveness, and data accuracy and work to avoid over-reliance on narrow data sources.