Epigenetic age and cardiometabolic disease in Guatemalan adults: a cross-sectional analysis

20260 citationsJournal Articlegold Open Access

Authors

Melissa Chapnick · Emory University

Elaine A. Yu · University of California, San Francisco

A. David Smith · Emory University

Karen N. Conneely · Emory University

Manuel Ramírez-Zea · Institute of Nutrition of Central America and Panama

Zhaohui S. Qin · Emory University

Lisa R. Staimez ·

Abstract

We observed consistent associations of accelerated DunedinPACE with multiple cardiometabolic conditions. All epigenetic clocks showed associations of epigenetic age acceleration with diabetes. These findings emphasize the need for longitudinal analyses to determine the direction and causality of these relationships.

Topics & Keywords

Epigenetics and DNA Methylation Birth, Development, and Health Genetic Associations and Epidemiology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Health Population and Nutrition

Volume 45, Issue 1

DOI: 10.1186/s41043-026-01255-4

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