Education on the Dangers of Exposure to Chemicals that Affect Male Reproduction and the Potential of Xanthone as an Antioxidant through the Nrf2-Keap1 and Gpx4 Pathways for PKK Mothers in RW 01 Sidomoro, Gresik

Exposure to hazardous chemicals such as 2-methoxyethanol has the potential to reduce reproductive health quality, particularly through damage to Leydig cells as producers of testosterone. The low level of public knowledge, especially among women in Family Welfare Movement (PKK) groups as key actors in family health, may lead to a lack of awareness of chemical risks and the importance of prevention efforts through healthy lifestyles and the use of natural antioxidant compounds such as xanthone. This community service activity aimed to increase the knowledge and understanding of PKK members in RW 01 Sidomoro, Gresik regarding the dangers of chemical exposure to male reproductive health and the role of xanthone in cellular protection mechanisms through the Nrf2–Keap1 and Gpx4 pathways. The methods used included educational counseling through interactive lectures, visual media, discussions, and question-and-answer sessions. Understanding was evaluated using pre-test and post-test questionnaires written in simple language. The activity was attended by 120 participants. The evaluation results showed that after the counseling, all 120 participants had received the information, with 110 people (91.7%) demonstrating good understanding of the dangers of 2-methoxyethanol, the function of Leydig cells, the role of xanthone as an antioxidant, and preventive measures that can be implemented at the family level. Meanwhile, 10 people (8.3%) had not fully understood the material, particularly the scientific terms and molecular mechanisms. Overall, this educational counseling activity was effective in improving reproductive health literacy and awareness of the importance of protection against chemical exposure. In conclusion, follow- up assistance and repetition of the material using more practical and visual approaches are needed to help all participants achieve optimal understanding.