Distinct activation thresholds of unmyelinated C-fiber afferents by dorsal root ganglion and peripheral nerve stimulation

20260 citationsJournal Articlegreen Open Access

Authors

Jia Liu · University of Maryland Eastern Shore

Shaopeng Zhang · University of Connecticut

Sajjad Rigi Ladez · University of Connecticut

Abstract

These findings identify a structural and molecular mechanism underlying the efficient activation of C-fiber afferents by DRG stimulation and provide mechanistic insight into the superior therapeutic efficacy of DRG stimulation for the treatment of C-fiber-mediated chronic pain.

Topics & Keywords

Pain Mechanisms and Treatments Pain Management and Treatment Ion Channels and Receptors

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.02.02.703367

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Distinct activation thresholds of unmyelinated C-fiber afferents by dorsal root ganglion and peripheral nerve stimulation

Authors

Abstract

Topics & Keywords

Publication Details