Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve

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Authors

Sébastien Thériault · Institut universitaire de cardiologie et de pneumologie de Québec

Jacob A. Holdcraft

Dinara Sharipova · University of Potsdam

Adèle Faucherre · Centre National de la Recherche Scientifique

Radosław Dębiec · NIHR Leicester Biomedical Research Centre

Gina M. Peloso · Université Laval

Baravan Al‐Kassou · University of Bonn

Abstract

This study supports a significant polygenic contribution to BAV, where the combination of multiple common variants in genes involved in heart morphogenesis disrupts aortic valve development.

Topics & Keywords

Congenital heart defects research Aortic Disease and Treatment Approaches Congenital Heart Disease Studies

Publication Details

Published in: Circulation

DOI: 10.1161/circulationaha.125.074752

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Genome and Transcriptome-Wide Analyses Identify Multiple Candidate Genes and a Significant Polygenic Contribution in Bicuspid Aortic Valve

Authors

Abstract

Topics & Keywords

Publication Details