Mechanisms of <scp> <i>SCN2A</i> </scp> loss of function do not predict presence or phenotype of epilepsy

Distinct SCN2A LoF phenotypes cannot be reliably linked to specific biophysical mechanisms, as both total and partial Na_v1.2 LoF occurs across diverse phenotypes. For efficient personalized treatment, it is crucial not to rely solely on clinical phenotype to predict the underlying LoF mechanism.