Masupirdine, a Selective Serotonin 5-HT <sub>6</sub> Receptor Antagonist for Alzheimer’s Disease

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Authors

Mireia Toledano-Pinedo · Instituto de Química Orgánica General

M. Mercedes Rodríguez-Fernández · Universidad Autónoma de Madrid

José Marco-Contelles · Instituto de Química Orgánica General

Abstract

Masupirdine is an oral, small, and safe molecule, readily available by a robust, two-step synthetic scheme, showing a potent, selective serotonin 5-HT<sub>6</sub> receptor antagonist profile, pro-cognitive effects in various behavioral animal models in Phase 3 clinical trials for the treatment of agitation in patients with Alzheimer's dementia.

Topics & Keywords

Neurotransmitter Receptor Influence on Behavior Nicotinic Acetylcholine Receptors Study Phosphodiesterase function and regulation

Publication Details

Published in: ACS Pharmacology & Translational Science

Volume 9, Issue 3, pp. 761-763

DOI: 10.1021/acsptsci.5c00818

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Masupirdine, a Selective Serotonin 5-HT <sub>6</sub> Receptor Antagonist for Alzheimer’s Disease

Authors

Abstract

Topics & Keywords

Publication Details