Association of Cortical Free Water With Brain Tau Tangle Load in the Alzheimer Disease Continuum

20262 citationsJournal Article

Authors

Brandon J Hall · Montreal Neurological Institute and Hospital

Étienne Aumont · Montreal Neurological Institute and Hospital

Seyyed Ali Hosseini · Montreal Neurological Institute and Hospital

Jaime Fernández Arias · Montreal Neurological Institute and Hospital

Arnaud Boré · Université de Sherbrooke

Gleb Bezgin · Montreal Neurological Institute and Hospital

Lydia Trudel

Abstract

In AD-relevant regions, increased free water correlates with tau load independently of macrostructural metrics or amyloid load. Free water may serve as an imaging marker for microstructural changes in gray matter resulting from NFT accumulation, complementary to macrostructural metrics.

Topics & Keywords

Cerebrospinal fluid and hydrocephalus Neurological and metabolic disorders Electrolyte and hormonal disorders

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Neurology

Volume 106, Issue 5, pp. e214606-e214606

DOI: 10.1212/wnl.0000000000214606

Field-Weighted Citation Impact: 46.59