Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates <scp>SIRT3</scp> and Attenuates Experimental Pulmonary Hypertension

Our findings underscore the role of sEH-P in the development and progression of PH, partly through its regulation of SIRT3 expression, cell proliferation, and apoptosis-related proteins. Targeting sEH-P emerges as a promising therapeutic strategy for PH.