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The “Patient Safety Caravan” is a patient safety promotion campaign launched by the Saudi Patient Safety Center and adopted by Riyadh Second Health Cluster hospitals to promote a culture of patient safety. It aimed to educate patients and their families about patient safety, promote patient empowerment, and provide information to help patients be actively involved in their own healthcare. The objective of this study is to report on the implementation of the campaign from November 2022 to December 2023 and evaluate patients’ satisfaction and feedback with the initiative. A prospective, intervention-based study was conducted in two phases-planning and implementation-across 11 hospitals within the Riyadh Second Health Cluster from November 2022 to December 2023. A total of 3,244 patients were engaged through structured visits by trained volunteers using standardized educational toolkits. Patient satisfaction was assessed using a 3-point Likert scale survey and open-ended feedback. Descriptive and thematic analyses were used to evaluate quantitative and qualitative data, respectively. Out of 3,244 patients engaged in the initiative, 604 completed the satisfaction survey. Among them, 96.2% reported satisfaction with the overall Patient Safety Caravan initiative, and 95.6% were satisfied with the educational toolkits. The involved patients’ feedback about the initiative and provided kits were adding more information about patients’ compliance with physicians’ and health educators’ orders and treatment plan, giving more detailed information about the initiative, focus on patients’ rights, and increase frequency of this initiative. Patient Safety Caravan Initiative was well received by patients, indicating that targeted patient engagement campaigns can successfully enhance patient satisfaction and awareness around safety practices. Broader adoption and continued refinement of such strategies may further empower patients and improve the overall quality of healthcare delivery. Not applicable.