Adenine Base Editing Potently Suppresses Hepatitis B Surface Antigen Expression and Inhibits Hepatitis D Virus Release

20260 citationsJournal Articlegreen Open Access

Authors

Anuj Kumar · Université Claude Bernard Lyon 1

Emmanuel Combe · Université Claude Bernard Lyon 1

Elena M. Smekalova · Beam Therapeutics (United States)

Selam Dejene · Beam Therapeutics (United States)

Dominique Leboeuf · Beam Therapeutics (United States)

Chao-Ying Chen · Beam Therapeutics (United States)

Léa Mougené

Abstract

Adenine base editing of the HBs ORF effectively impairs HBV replication and HBsAg production in vitro and in vivo and concomitantly inhibits HDV release, highlighting its therapeutic potential.

Topics & Keywords

Hepatitis B Virus Studies CRISPR and Genetic Engineering Hepatitis Viruses Studies and Epidemiology

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.02.06.704371

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