Comparative efficacy and safety of chlorthalidone <i>vs</i> hydrochlorothiazide in hypertension management: A systematic review and meta-analysis

The present meta-analysis suggests that chlorthalidone is more effective than hydrochlorothiazide in reducing both systolic and diastolic blood pressure, particularly at night. Although both drugs share comparable cardiovascular event safety profiles, chlorthalidone carries a higher risk of inducing hypokalemia. These findings emphasize the need for individualized treatment strategies in the management of hypertension based on the varying efficacy and safety profiles of chlorthalidone and hydrochlorothiazide.