A Human Monoclonal Antibody Displays Promiscuous Binding to Multiple Type 1 nsLTP Allergens

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Authors

Gage O. Leighton · National Institute of Environmental Health Sciences

L.G. Pedersen · National Institute of Environmental Health Sciences

Jungki Min · National Institute of Environmental Health Sciences

Paige Creeks · Nurix (United States)

Scott A. Gabel · National Institute of Environmental Health Sciences

Lalith Perera · National Institute of Environmental Health Sciences

Thomas Randall

Abstract

IGX-3103 is an example of a human mAb with cross-reactivity to pollen, fruit, and seed type 1 nsLTPs. This observation anecdotally supports the possibility that a few promiscuous mAbs could be driving cross-reactivity.

Topics & Keywords

Food Allergy and Anaphylaxis Research Allergic Rhinitis and Sensitization Mast cells and histamine

UN Sustainable Development Goals

Zero hunger

Publication Details

Published in: Journal of Investigational Allergology and Clinical Immunology

Volume 37, Issue 1, pp. 0-0

DOI: 10.18176/jiaci.1143

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