Comparative Effectiveness of Brivaracetam, Cenobamate, Lacosamide, and Perampanel in Focal Epilepsy

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Authors

Emanuele Cerulli Irelli · Sapienza University of Rome

Roberta Roberti · Magna Graecia University

Maria Sole Borioni · Sapienza University of Rome

Francesca Anzellotti · Ospedale SS. Annunziata

Vincenzo Belcastro · Aziende Socio Sanitarie Territoriale Lodi

Simone Beretta · Azienda Ospedaliera San Gerardo

Giovanni Boero

Abstract

These study findings suggest superior effectiveness of cenobamate over brivaracetam, lacosamide, and perampanel in adults with drug-resistant focal epilepsy in a large real-world setting.

Topics & Keywords

Epilepsy research and treatment Neuroscience and Neuropharmacology Research Pharmacological Effects and Toxicity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JAMA Neurology

DOI: 10.1001/jamaneurol.2025.5625

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