Long-term left ventricular assist device support reinforces detrimental immunological effects

20260 citationsJournal Articlegold Open Access

Authors

M T H Dieterlen · Helios Park-Klinikum Leipzig

Malina Sauskat · Helios Park-Klinikum Leipzig

Kristin Klaeske · Helios Park-Klinikum Leipzig

Eva Katharina Messer · Helios Park-Klinikum Leipzig

Joanna Jozwiak-Nozdrzykowska · Leipzig Heart Institute

Alexey Dashkevich · Helios Park-Klinikum Leipzig

Michael A. Borger

Abstract

This cross-sectional observational study revealed that long-term (≥36 months) LVAD support may contribute to detrimental effects on the immune system in comparison to short-term LVAD support. The long-lasting LVAD support may influence DCs, NK cells and B-cells that show a progression of cellular changes.

Topics & Keywords

Mechanical Circulatory Support Devices Transplantation: Methods and Outcomes Cardiac Fibrosis and Remodeling

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Frontiers in Immunology

Volume 17, pp. 1705980-1705980

DOI: 10.3389/fimmu.2026.1705980

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