Enhancing NK Cell Activity in Colorectal Cancer with an Fc-Optimized Antibody Targeting CD276 (B7-H3)

20260 citationsJournal Articlegold Open Access

Authors

Sylwia A. Stefańczyk · Research Institute for Work, Technology and Culture

Xenija Kaiser · Research Institute for Work, Technology and Culture

Ilona Hagelstein · Research Institute for Work, Technology and Culture

Martina S. Lutz · Research Institute for Work, Technology and Culture

Samuel J. Holzmayer · Research Institute for Work, Technology and Culture

Latifa Zekri · Research Institute for Work, Technology and Culture

Abstract

The Fc-optimized anti-CD276 antibody 8H8_SDIE effectively enhanced NK cell reactivity against CD276-positive CRC cells and induced tumor cell lysis in vitro. These findings suggest that 8H8_SDIE holds potential as a novel immunotherapeutic candidate for CRC, particularly for patients with microsatellite-stable disease, and warrants further evaluation in advanced preclinical and future clinical studies.

Topics & Keywords

Monoclonal and Polyclonal Antibodies Research Immune Cell Function and Interaction T-cell and B-cell Immunology

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: ImmunoTargets and Therapy

Volume Volume 15, pp. 1-14

DOI: 10.2147/itt.s533342

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