SDC1 <sup>+</sup> CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers

20260 citationsJournal Articlehybrid Open Access

Authors

Guan-Feng Gao · Sun Yat-sen University

Zhao-Hui Ruan · Central South University

Shi-Bo Zhang · Sun Yat-sen University

Shuai He · Sun Yat-sen University

Yiqi Li · Sun Yat-sen University

Jin-Li Lyu · Sun Yat-sen University

Ying Liu ·

Abstract

Our study establishes SDC1<sup>+</sup> CAFs as a universal, metastasis-promoting CAF subset across multiple cancer types and uncovers a novel KLF6-CTGF-FGFR3 axis that drives EMT and tumour dissemination. These findings provide mechanistic insight into CAF-tumour cell crosstalk and highlight actionable stromal targets for anti-metastatic therapies across diverse malignancies.

Topics & Keywords

Connective Tissue Growth Factor Research Cancer Cells and Metastasis Fibroblast Growth Factor Research

UN Sustainable Development Goals

No poverty

Publication Details

Published in: Gut

DOI: 10.1136/gutjnl-2025-337606

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