Immunometabolic transcriptomic signatures of diabetes-related genes predict kidney transplant rejection

We identified a distinct metabolic gene signature capable of predicting kidney transplant rejection. The downregulation of <i>DPP4</i> with the upregulation of <i>PPARG</i> and <i>INSR</i> suggests that metabolic reprogramming and loss of homeostasis are hallmarks of immune-mediated graft failure.