Creatinine, leucine, and tetrahydrocorticosterone emerge as potential biomarkers for the diagnosis of sarcopenic osteoarthritis in middle-aged and elderly individuals: a cross-sectional exploratory study

Untargeted serum metabolomics successfully distinguished between healthy controls, osteoarthritis, and sarcopenic osteoarthritis and identified several candidate biomarkers. Creatinine, leucine, and tetrahydrocorticosterone emerged as promising biomarkers for the detection and phenotyping of the distinct sarcopenic osteoarthritis phenotype based on their clinical relevance and ease of measurement.