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Joint disorders, such as osteoarthritis of the lower extremities, are progressive degenerative conditions characterized by cartilage loss, subchondral bone remodeling, and synovial inflammation, leading to pain, stiffness, and reduced function. Tendon disorders, particularly in the knee and ankle regions, are also common musculoskeletal complaints affecting not only elderly individuals but also younger patients and athletes. While traditionally regarded as mechanical “wear-and-tear” conditions, current insights emphasize the pivotal role of pathological hypervascularization and associated nociceptive nerve in growth within the synovium, tendons, subchondral bone, and osteophytes—mechanisms aligned with the vascular–neural framework. These fragile, inflamed microvessels sustain synovitis or tenosynovitis, intensify pain signaling, and accelerate structural deterioration, especially in individuals with established risk factors such as aging, obesity, prior injury, or biomechanical overload. Regenerative and biologic therapies, including platelet-rich plasma (PRP), stem cell treatments, and molecular anti-inflammatory agents, aim to restore joint homeostasis. In addition, vascular-targeted techniques such as Dochu offer an alternative pathway for addressing pathological hypervascularity. Viewing these conditions through an integrated biomechanical and vascular perspective opens the door to minimally invasive interventions designed to alleviate pain, improve mobility, and potentially slow disease progression.