Spatiotemporal Encoding With Nonlinear Gradient Hardware Using Pulseq: From Principles to Practical Demonstration

The generation of the SPEN-defining quadratic phase using nonlinear gradients is an advantageous alternative to conventional methods. This approach enables improved clinical applicability of SPEN, particularly for 3D and high-field MRI, by mitigating critical safety and timing limitations. Additionally, an implementation of the conventional method is provided open-source to support further research.