Evaluating the Effectiveness of Cyproheptadine on Acute Neuroleptic-induced Akathisia

Cyproheptadine significantly reduces symptoms of antipsychotic-induced akathisia. Based on the evidence of this study, particularly the ARR and the NNT for achieving complete remission, it seems that cyproheptadine could be a potential alternative for managing akathisia induced by antipsychotic medications, especially in comparison to previous studies involving mirtazapine and propranolol.