A Double-Blinded, Split-Face Clinical Trial Evaluating the Effects of a Vitamin C, E, and Ferulic Acid Serum Combined with Microneedling on Facial Photoaging

Combining topical antioxidant serum with microneedling provides superior outcomes for facial rejuvenation than microneedling alone. This combination protocol significantly improves clinical signs of photoaging, including skin elasticity, rhytides, and dyspigmentation, suggesting an optimized treatment protocol with minimal recovery time.