Effects of Heat-Killed Lactobacillus acidophilus IDCC 3302 on Skin Aging Parameters: A Randomized, Double-Blind, Placebo-Controlled Trial in Healthy Adults

The 12-week supplementation with ID-ACT 3302 was safe and well tolerated. However, no placebo-adjusted benefit was observed for the prespecified primary wrinkle endpoints. An exploratory between-group difference was observed for the Cutometer overall elasticity index (R2), but because secondary endpoints were not multiplicity-adjusted and the effect size was small, this finding should be interpreted as hypothesis-generating and requires confirmation in adequately powered trials.