Optical Waveguide Lightmode Spectroscopy: A Versatile Technique for Real-Time, Label-Free Biosensing

Optical waveguide lightmode spectroscopy (OWLS) is an integrated-optical technique for probing structures at the solid/gas and solid/liquid interface. Spatial resolution perpendicular to the interface is sub-ångström. Thanks to good time resolution, processes involving structural change can also be investigated. This review covers the fundamentals of the technique, the various measurement configurations that are used, interpretation of the primary data received, applications in biosensing, and future prospects.