Use of dietary and herbal supplements and communication with hematologists regarding such use among patients with CLL: a national survey

Use of dietary and herbal supplements (DHS) is common among patients with chronic lymphocytic leukemia (CLL), but data in the era of targeted therapies are limited. We conducted a national prospective survey of Hebrew-speaking adults with CLL in Israel (2025), assessing DHS prevalence, patterns of use, sources of recommendation, reporting to hematologists, and patient expectations. Multivariate logistic regression identified factors associated with DHS use. Among 267 respondents, 49% reported current or past DHS use. Use was independently associated with female gender and residence in Central Israel. Most DHS were used for general or 'immune' strengthening, with high perceived effectiveness. Hematologists were the main advisors for 42% of DHS use, and 65% of patients disclosed DHS use to their physician. DHS use is common among patients with CLL and involves relatively high patient-hematologist communication, underscoring the need for evidence-based integrative counseling.