Alternative Synthesis of Click Sphingosine via Olefin Cross Metathesis Followed by the Seyferth–Gilbert Reaction

20260 citationsJournal Article

Authors

Sergei M. Korneev · Joint Stock Company National Research Institute Electron

V. A. Polukeev · Joint Stock Company National Research Institute Electron

Andrei V. Khramchikhin · St. Petersburg State Technological Institute

Abstract

ABSTRACT An alternative path to obtain three terminally functionalized sphingosines with acetylene, aldehyde, and carboxyl functions using olefin metathesis as a key step is reported. All these analogues of natural sphingosine can be used for imaging or derivatization.

Topics & Keywords

Synthetic Organic Chemistry Methods Sphingolipid Metabolism and Signaling Pharmacological Receptor Mechanisms and Effects

Publication Details

Published in: ChemistrySelect

Volume 11, Issue 6

DOI: 10.1002/slct.202507097

Field-Weighted Citation Impact: 0.00

Command Palette

Alternative Synthesis of Click Sphingosine via Olefin Cross Metathesis Followed by the Seyferth–Gilbert Reaction

Authors

Abstract

Topics & Keywords

Publication Details