Loss of Myofilaments in Gastrointestinal Smooth Muscle: A Novel Pathological Finding in <scp>MELAS</scp> ‐Associated Chronic Intestinal Pseudo‐Obstruction

This represents the first report of myofilament loss in MELAS-associated CIPO, suggesting that mitochondrial dysfunction may directly impair smooth muscle contractile apparatus beyond previously described neuronal abnormalities. These findings provide novel insights into CIPO pathogenesis and may inform therapeutic strategies emphasizing early enteral nutrition interventions that bypass affected gastrointestinal segments.