Baseline Regional Cholinergic Denervation Predicts Cognitive Trajectories in Moderate Parkinson Disease

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Authors

Taylor Brown · University of Michigan

Giulia Carli · University of Michigan

Prabesh Kanel · University of Michigan

Stiven Roytman · University of Michigan

Jaimie Barr · University of Michigan

Nicolaas I. Bohnen · University of Michigan

Roger Albin ·

Abstract

Baseline cholinergic system changes associate with varying cognitive trajectories in mild-moderate PD. Assessment of regional cholinergic deficits may be useful for prediction of cognitive trajectories in this population, enhancing subject selection and stratification for intervention trials aimed at improving cognition in PD.

Topics & Keywords

Parkinson's Disease Mechanisms and Treatments Nicotinic Acetylcholine Receptors Study Neurological disorders and treatments

UN Sustainable Development Goals

Quality Education

Publication Details

Published in: Annals of Clinical and Translational Neurology

DOI: 10.1002/acn3.70335

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