Age and the relation of common neuropathologies to dementia in Brazilian adults

In a community-based, clinical-pathologic study including 5300+ brains from diverse Brazilians, we show that AD and other common pathologies frequently begin in young adulthood. In older adults, mixed pathologies are most commonly associated with dementia, whereas in young adults a single pathology, most commonly chronic gross infarcts rather than ADNC is related to dementia.