Chikungunya virus‐induced persistent allodynia is accompanied by joint microenvironmental changes and involves cartilage degradation and TRPA1 activation

Insights into CHIKV-associated pain have been made giving a guide to targeted analgesic strategies. CHIKV or its RNA injection triggers bilateral secondary mechanical allodynia, accompanied by knee joint damage and a TRPA1-dependent mechanism. Indicating TRPA1 blockers have the potential to be repurposed or further investigated for the clinical management of CHIKV-associated chronic pain.