The endothelial plasma membrane lipidome and its remodeling under hyperglycemia: an exploratory study

The hyperglycemia-induced alterations provide insights into the endothelial membrane lipid environment and the biophysical dynamics that are likely to deregulate protein-lipid interactions involved in sugar and lipid metabolism. The high amount of Chol found in our work serves as the basis for future <i>in silico</i> simulations crucial for drug design and drug response evaluation.