Collagen I alleviates UVB-induced oxidative DNA damage and inhibits YAP-p73 apoptotic pathway in human keratinocytes HaCaT

20260 citationsJournal Article

Authors

Yuying Zhu · Shenyang Pharmaceutical University

Weiwei Liu · Shenyang Pharmaceutical University

Tianyu Ji · Shenyang Pharmaceutical University

Zhao San · Shenyang Pharmaceutical University

Ruiyi Cao · Shenyang Pharmaceutical University

Toshihiko Hayashi · Shenyang Pharmaceutical University

K. Mizuno ·

Abstract

Collagen I-coating protects UVB-irradiated cells from YAP-p73 mediated apoptosis through restricting ROS production and thus alleviating DNA damages, owing to the restored mitophagy. Our study supports the clinical application of collagen products as anti-UVB agents.

Topics & Keywords

Hippo pathway signaling and YAP/TAZ Collagen: Extraction and Characterization Skin Protection and Aging

Publication Details

Published in: Connective Tissue Research

DOI: 10.1080/03008207.2026.2630869

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Collagen I alleviates UVB-induced oxidative DNA damage and inhibits YAP-p73 apoptotic pathway in human keratinocytes HaCaT

Authors

Abstract

Topics & Keywords

Publication Details