Abstract PS4-11-27: Acceptability of a web-based narrative video intervention to promote clinical trial decision making among Black women with breast cancer

Abstract Background: Black women are more likely to present with advanced stage disease and to die following a breast cancer (BC) diagnosis compared with women from other racial and ethnic groups. This persistent health inequity is in part driven by underrepresentation in clinical trials (CTs), as well as structural and social drivers of health. Objective: The overall objective of this study is to develop, optimize, and pilot-test a narrative decision aid (web-based video) that is culturally sensitive, grounded in a socioecological framework, informed by in-depth, iterative, and community-engaged qualitative research, and designed to support clinical trial decision-making among Black breast cancer patients receiving care in safety-net oncology settings. Here, we report outcomes from an acceptability study conducted at a safety-net oncology practice among end-users. Methods: To assess acceptability of the web-based, narrative video intervention, we conducted a study in a clinic population at the University of Illinois Cancer Center oncology clinic. Black women with a diagnosis of BC (any stage, any point during treatment or follow-up) were identified by their oncologist and invited to participate,. Consenting participants completed a paper-based pre-survey, viewed the 12-minute video intervention on an electronic device, and completed a paper-based post-survey. The survey included items related to demographics, prior exposure to clinical trials, clinical trial knowledge, self-efficacy, and video acceptability. Participants received $50 for completing all study activities. Data were entered into a REDCap database and exported to SPSS for analysis. We calculated descriptive statistics (mean, standard deviation) for pre- and post-intervention scores and used paired t-tests to analyze the change in scores from pre- to post-intervention. Results: Twenty Black BC patients participated in the study. Prior to the intervention, 85% reported that a member of their medical team had discussed clinical trials, 75% had been invited to participate, and 60% had previously enrolled in a clinical trial. The correct response rate to 5 items on clinical trial knowledge increased from 85.8% at baseline to 92.0% post-viewing (p = 0.029). Confidence in making an informed decision about clinical trials also improved significantly. Self-efficacy was measured using an 11-item scale (0 = not at all confident; 4 = very confident); mean scores increased from 3.35 at baseline to 3.50 post-viewing (p < 0.001). At baseline, 75% of participants strongly agreed or agreed with the statement, “If I had the option, I would definitely consider joining a clinical trial;” this increased to 85% post-viewing. The video was highly acceptable: 100% of participants indicated they were extremely or somewhat likely to share it with family or friends; 95% would not change anything about the video; 80% reported it would motivate them or a loved one to speak with their doctor about clinical trials; and 80% found the content trustworthy. Conclusions: This study demonstrated that a culturally tailored, narrative-based video intervention is both acceptable to Black breast cancer patients and associated with improvements in clinical trial knowledge, decision-making self-efficacy, and intention to participate in trials. These findings support the feasibility of implementing such interventions in safety-net oncology settings. A pilot study of the intervention with a quasi-experimental design is ongoing and will evaluate whether integrating the intervention into standard education for newly diagnosed Black BC patients is associated with increase in clinical trial enrollment. Results of the pilot study will be presented. Citation Format: N. Hippalgaonkar, D. Patel, C. Hollahan, A. White, M. Carrasquillo, M. Karan, R. Warren, M. Kromm, G. Vass, P. Khosla, V. Henderson, K. Hoskins, L. Carnahan, R. Nguyen Acceptability of a web-based narrative video intervention to promote clinical trial decision making among Black women with breast cancer [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2025; 2025 Dec 9-12; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2026;32(4 Suppl):Abstract nr PS4-11-27.