Dementia with Lewy bodies and additional progressive supranuclear palsy presenting with early postural instability and frequent falls: an autopsy case

This case illustrates that comorbid DLB and PSP can produce an atypical phenotype showing core features of DLB, early severe postural instability, and frequent falls. We believe that dual involvement of tau and α-synuclein pathologies in the mesencephalic locomotor region in the midbrain tegmentum contributed to gait disturbances and falls, leading to cerebral contusion and traumatic subarachnoid hemorrhage.