Structural Basis for Trivalent Cross‐Linking of a Patient‐Derived <scp>IgE</scp> Antibody by the Major Peanut Allergen Ara h 2.0201

The trivalent binding is effective in forming large allergen-IgE complexes on mast cell or basophil surfaces and contributes to the potency of Ara h 2 in triggering allergic reactions and highlighting its role in anaphylaxis. Proline hydroxylation considerably enhances D08 binding affinity and contributes to cross-reactivity among Ara h 1-3 allergens.