Validation of CURB-65, CRB-65, NEWS2, qSOFA, and 4C scores for predicting mortality in COVID-19 patients across seven emergency Departments in Colombia

The 4C Mortality Score outperformed other models in predicting COVID-19 mortality. Its use in emergency settings alongside clinical judgment can enhance risk stratification, guide hospitalization decisions, and optimize resource allocation. Recalibration and decision analysis are essential for its clinical applicability. Further validation with contemporary data is essential to ensure its transportability across epidemiological settings.