Clinical Heterogeneity in Orthostatic Movement Disorders: Insights from Latent Class Analysis and Disease Burden Scoring

20260 citationsJournal Article

Authors

Anish Mehta · M.S. Ramaiah Medical College

Thyagarajan Shivashanmugam · Asha Foundation

Michiko Kimura Bruno · University of Hawaiʻi at Mānoa

Louis C.S. Tan · National Neuroscience Institute

Pramod Kumar Pal · National Institute of Mental Health and Neurosciences

Abstract

Multidomain clinical data enable disease-burden stratification and reveal phenotypic heterogeneity in orthostatic movement disorders. Limited correspondence with traditional diagnoses supports a spectrum-based model. DBS and LCA offer complementary frameworks for individualized assessment, warranting validation in larger and longitudinal cohorts.

Topics & Keywords

Neurological disorders and treatments Cardiovascular Syncope and Autonomic Disorders Neurological and metabolic disorders

Publication Details

Published in: Movement Disorders Clinical Practice

DOI: 10.1002/mdc3.70563

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Clinical Heterogeneity in Orthostatic Movement Disorders: Insights from Latent Class Analysis and Disease Burden Scoring

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Abstract

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Publication Details