Dynamics of Varicella Zoster Virus-Specific Immune Reconstitution and Impact of Varicella Vaccination in Pediatric Allogeneic Hematopoietic Stem Cell Transplant Recipients

Varicella-zoster virus-specific T-cell-mediated immunity in pediatric hematopoietic stem cell transplant recipients remained low in the first 3 months but recovered significantly by 2 years post-hematopoietic stem cell transplant, with a boosting effect from varicella vaccination. Further studies are needed to assess the clinical significance of T-cell-mediated immunity and to guide personalized prevention strategies.